The Seguin-Guadalupe County Heritage Museum is dedicated to its collection of, and preservation and conservation of historical materials representative of the South Central Texas Region. This includes but is not limited to the areas of business, religious denominations, the arts and sciences, education, technology, agriculture and other institutions which have contributed to the history of this region.

The Heritage Museum is housed in the former Red and White Grocery Store owned by the Baenziger family of Seguin, Texas. Mr. Henry Troell constructed the red brick building in 1898 on the north-west corner of North River Street and East Gonzales Street. It is a two-storey structure with a balcony facing River Street.

At the Seguin-Guadalupe County Heritage Museum, thousands of years of history comes alive in the objects that are on the display. Since being formed in 1997, the museum's permanent collection has grown to tens of thousands of objects from prehistoric artifacts to ceramics, jewelry, textiles, utility items, photographs, and numerous installations.