The MFACM's Permanent Collection of 4,000 pieces covers 3,000 years of Mexican history. The artwork in the Collection ranges from pre-Cuauhtémoc Mexican artifacts to contemporary Mexican art. The Collection contains works by an equal number of Mexican artists from Mexico, Mexican American artists, and Chicago Mexican artists.

Each exhibition at the MFACM is accompanied by a wide variety of educational programming. Family Days, lectures, film screenings, readings, artist demonstrations, art classes, and workshops are some of the things that the Museum Education Department offers. Nearly all Museum programming is free.

The MFACM's youth initiatives, the Yollocalli Youth Museum and Radio Arte WRTE 90.5 FM are both completely free job training and arts education programs for young people ages 13-21. For more information please visit their websites, yollocalli.org and radioarte.org.