Housed in the historic Kress building in downtown Blytheville, Arkansas, Delta Gateway Museum collects, stores, maintains, and regularly exhibits historical and cultural objects, artifacts, photographs, works of art, printed materials, and audio-visual materials that relate to and emphasize the history, heritage, and culture of NE Arkansas, SE Missouri, and the Mississippi River Delta.

The mission of Delta Gateway Museum is to tell the story of Blytheville and the surrounding area by interpreting the land and its impact on the people.